ORIGINAL PAPER
Psychosocial adjustment to illness and resilience in inflammatory bowel disease outpatients: cross-sectional evidence from Serbia
 
More details
Hide details
1
Institute of Criminological and Sociological Research, Belgrade, Serbia
 
2
Clinical Hospital Center Zvezdara, Belgrade, Serbia
 
 
Submission date: 2025-11-21
 
 
Final revision date: 2026-02-20
 
 
Acceptance date: 2026-02-20
 
 
Online publication date: 2026-04-30
 
 
Corresponding author
Violeta Tadić   

Institute of Criminological and Sociological Research, Belgrade, Serbia
 
 
 
KEYWORDS
TOPICS
ABSTRACT
Background:
This study aimed to examine psychosocial adjustment to illness and resilience among outpatients with inflammatory bowel disease (IBD) in Serbia and to evaluate the predictive role of resilience.

Participants and procedure:
A cross-sectional survey was conducted among 109 IBD outpatients (47 with Crohn’s disease and 62 with ulcerative colitis). Participants completed standardized measures of resilience and psychosocial adjustment across multiple life domains, along with sociodemographic data. Statistical analyses included descriptive statistics, correlations, and multivariate regression to assess associations between resilience and psychosocial adjustment.

Results:
Participants demonstrated moderate to high levels of resilience and psychosocial adjustment. The highest adjustment scores were observed in personal health care, illness-related behavior, and treatment comprehension, whereas vocational and domestic domains were more affected. Regression analysis revealed that resilience significantly predicted psychosocial adjustment across several domains (i.e., personal health care, emotional response and hope for recovery, physician-provided information, treatment comprehension, social environment, and psychological distress). Notably, resilience was inversely associated with reliance on physician-provided illness information.

Conclusions:
Resilience emerged as a key predictor of psychosocial adjustment in IBD, influencing emotional, social, and cognitive do-mains of functioning. Strengthening resilience and adaptive coping capacities should be considered essential components of comprehensive IBD care, complementing medical interventions and enhancing overall functioning and long-term outcomes. Future research should examine longitudinal effects of resilience and evaluate targeted interventions aimed at improving quality of life in IBD populations.
REFERENCES (50)
1.
Achtenberg, M., Cibor, D., & Zwolińska-Wcisło, M. (2025). Structured exercise in patients with inflammatory bowel disease: a literature review. Gastroenterology Review, 20, 36–40. https://doi.org/10.5114/pg.202....
 
2.
Argyriou, K., Kapsoritakis, A., Oikonomou, K., Manolakis, A., Tsakiridou, E., & Potamianos, S. (2017). Disability in patients with inflammatory bowel disease: Correlations with quality of life and patient’s characteristics. Cana-dian Journal of Gastroenterology & Hepatology, 2017, 6138105. https://doi.org/10.1155/2017/6....
 
3.
Alsheikh, A. S., & Alqudah, A. (2023). Examine the role of psychological resilience in predicting social and profes-sional performance in patients with diabetes, multiple sclerosis, and rheumatism. Health Psychology Research, 11, 73350. https://doi.org/10.52965/001c.....
 
4.
Ayed, N., Toner, S., & Priebe, S. (2019). Conceptualizing resilience in adult mental health literature: a systematic review and narrative synthesis. Psychology & Psychotherapy: Theory, Research & Practice, 92, 299–341. https://doi.org/10.1111/papt.1....
 
5.
Ballou, S., & Keefer, L. (2017). Psychological interventions for irritable bowel syndrome and inflammatory bowel diseases. Clinical and Translational Gastroenterology, 8, e214. https://doi.org/10.1038/ctg.20....
 
6.
Bannaga, A. S., & Selinger, A. (2015). Inflammatory bowel disease and anxiety: Links, risks, and challenges faced. Clinical and Experimental Gastroenterology, 8, 111–117. https://doi.org/10.2147/CEG.S5....
 
7.
Bernhofer, E. I., Masina, V. M., Sorrell, J., & Modic, M. B. (2017). The pain experience of patients hospitalized with inflammatory bowel disease: a phenomenological study. Gastroenterology Nursing, 40, 200–207. https://doi.org/10.1097/SGA.00....
 
8.
Byron, C., Cornally, N., Burton, A., & Savage, E. (2020). Challenges of living with and managing inflammatory bowel disease: a meta-synthesis of patients’ experiences. Journal of Clinical Nursing, 29, 305–319. https://doi.org/10.1111/jocn.1....
 
9.
Cheng, L., Jetha, A., Cordeaux, E., Lee, K., & Gignac, M. A. M. (2022). Workplace challenges, supports, and ac-commodations for people with inflammatory bowel disease: a scoping review. Disability and Rehabilitation, 44, 7587–7599. https://doi.org/10.1080/096382....
 
10.
Cococcia, S., Lenti, M. V., Mengoli, C., Klersy, C., Borrelli de Andreis, F., Secco, M., Ghorayeb, J., Delliponti, M., Corazza, G. R., & Di Sabatino, A. (2021). Validation of the Italian translation of the perceived stigma scale and resilience assessment in inflammatory bowel disease patients. World Journal of Gastroenterology, 27, 6647–6658. https://doi.org/10.3748/wjg.v2....
 
11.
Dai, W., Zeng, Y., Liang, E., Zhou, Q., Zhang, L., & Peng, J. (2022). The actuality of resilience, social support and quality of life among patients with inflammatory bowel disease in China. Nursing Open, 9, 2190–2198. https://doi.org/10.1002/nop2.9....
 
12.
Derogatis, L. R. (1986). The Psychosocial Adjustment to Illness Scale (PAIS). Journal of Psychosomatic Research, 30, 77–91. https://doi.org/10.1016/0022-3....
 
13.
Dorrian, A., Dempster, M., & Adair, P. (2009). Adjustment to inflammatory bowel disease: The relative influence of illness perceptions and coping. Inflammatory Bowel Diseases, 15, 47–55. https://doi.org/10.1002/ibd.20....
 
14.
Engel, K., Homsi, M., Suzuki, R., Helvie, K., Adler, J., Plonka, C., & Zimmermann, E. (2021). Newly diagnosed pa-tients with inflammatory bowel disease: The relationship between perceived psychological support, health-related quality of life, and disease activity. Health Equity, 5, 42–48. https://doi.org/10.1089/heq.20....
 
15.
Fan, H., Zhang, B., & Wang, W. (2017). Family functions in relation to behavioral and psychological disorders in Chinese culture. The Family Journal, 25, 130–136. https://doi.org/10.1177/106648....
 
16.
Ferrarese, D., Vecchione, M., Spagnolo, G., Mirijello, A., Di Vincenzo, F., Belella, D., Camardese, G., D’Onofrio, A. M., Mora, V., Napolitano, D., Cammarota, G., Scaldaferri, F., Chieffo, D. P. R., Gasbarrini, A., Dionisi, T., & Addolorato, G. (2025). The role of resilience in mitigating depression and anxiety in patients with inflamma-tory bowel diseases. Journal of Psychosomatic Research, 196, 112309. https://doi.org/10.1016/j.jpsy....
 
17.
Gomez, D. A., Ahmad Waqar, M., Brookes, M. J., & Kumar, A. (2023). IBD-related mental health disorders: Where do we go from here? Frontline Gastroenterology, 14, 512–520. https://doi.org/10.1136/flgast....
 
18.
Haapamäki, J., Heikkinen, E., Sipponen, T., Roine, R. P., & Arkkila, P. (2018). The impact of an adaptation course on health-related quality of life and functional capacity of patients with inflammatory bowel disease. Scandina-vian Journal of Gastroenterology, 53, 1074–1078. https://doi.org/10.1080/003655....
 
19.
Hawkins, R. L., Zia, M., Hind, D., & Lobo, A. J. (2024). Inequalities in healthcare access, experience and outcomes in adults with inflammatory bowel disease: a scoping review. Inflammatory Bowel Diseases, 30, 2486–2499. https://doi.org/10.1093/ibd/iz....
 
20.
Irving, P., Barrett, K., Nijher, M., & de Lusignan, S. (2021). Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: Population-based cohort study. Evidence Based Mental Health, 24, 102–109. https://doi.org/10.1136/ebment....
 
21.
Ito, M., Togari, T., Park, M. J., & Yamazaki, Y. (2008). Difficulties at work experienced by patients with inflamma-tory bowel disease (IBD) and factors relevant to work motivation and depression. Japanese Journal of Health & Human Ecology, 74, 290–310. https://doi.org/10.3861/jshhe.....
 
22.
Jin, Y., Bhattarai, M., Kuo, W. C., & Bratzke, L. C. (2023). Relationship between resilience and self-care in people with chronic conditions: a systematic review and meta-analysis. Journal of Clinical Nursing, 32, 2041–2055. https://doi.org/10.1111/jocn.1....
 
23.
Kiebles, J. L., Doerfler, B., & Keefer, L. (2010). Preliminary evidence supporting a framework of psychological ad-justment to inflammatory bowel disease. Inflammatory Bowel Diseases, 16, 1685–1695. https://doi.org/10.1002/ibd.21....
 
24.
Kilpatrick, L. A., Gupta, A., Love, A., Labus, J. S., Alaverdyan, M., Tillisch, K., Naliboff, B. D., & Mayer, E. A. (2015). Neurobiology of psychological resilience in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) patients. Gastroenterology, 148, S774. https://doi.org/10.1016/S0016-....
 
25.
Lazarus, R., & Folkman, S. (1984). Stress, appraisal, and coping. Springer.
 
26.
Le Berre, C., Peyrin-Biroulet, L., Buisson, A., Olympie, A., Ravel, M. H., Bienenfeld, C., & Gonzalez, F. (2019). Im-pact of inflammatory bowel diseases on working life: a French nationwide survey. Digestive and Liver Disease, 51, 961–966. https://doi.org/10.1016/j.dld.....
 
27.
Luo, D., Zhou, M., Sun, L., Lin, Z., Bian, Q., Liu, M., & Ren, S. (2021). Resilience as a mediator of the association between perceived stigma and quality of life among people with inflammatory bowel disease. Frontiers in Psy-chiatry, 12, 709295. https://doi.org/10.3389/fpsyt.....
 
28.
Mattila, K., Rankala, R., Voutilainen, M., & Mustonen, A. (2022). Inflammatory bowel disease: Perceived impact on leisure time activities. Scandinavian Journal of Gastroenterology, 57, 930–935. https://doi.org/10.1080/003655....
 
29.
Matini, L., & Ogden, J. (2016). A qualitative study of patients’ experience of living with inflammatory bowel dis-ease: a preliminary focus on the notion of adaptation. Journal of Health Psychology, 21, 2493–2502. https://doi.org/10.1177/135910....
 
30.
Mendiolaza, M., Vicioso, C., Siddiqui, W., Lingineni, K., Gorbenko, K., Agarwal, P., & Keefer, L. (2025). Initial de-velopment and validation of a disease-specific resilience measure for inflammatory bowel disease: the RISE-IBD instrument. BMC Gastroenterology, 25, 390. https://doi.org/10.1186/s12876....
 
31.
Napolitano, D., Bozzetti, M., Lo Cascio, A., De Stefano, G., Orgiana, N., Lopetuso, L. R., D’Onofrio, A. M., Camardese, G., Papa, A., Scaldaferri, F., Cocchieri, A., & Bartoli, D. (2025). Resilience and self-care in patients with inflammatory bowel disease: a multicentre cross-sectional study in outpatient settings. Journal of Clinical Medicine, 14, 3868. https://doi.org/10.3390/jcm141....
 
32.
Ng, S. C., Shi, H. Y., Hamidi, N., Underwood, F. E., Tang, W., Benchimol, E. I., Panaccione, R., Ghosh, S., Wu, J. C. Y., Chan, F. K. L., Sung, J. J. Y., & Kaplan, G. G. (2017). Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet, 390, 2769–2778. https://doi.org/10.1016/S0140-....
 
33.
Oliveira, S., Zaltman, C., Elia, C., Vargens, R., Leal, A., Barros, R., & Fogaça, H. (2007). Quality of life measurement in patients with inflammatory bowel disease receiving social support. Inflammatory Bowel Diseases, 13, 470–474. https://doi.org/10.1002/ibd.20....
 
34.
Palant, A., & Himmel, W. (2019). Are there also negative effects of social support? A qualitative study of patients with inflammatory bowel disease. BMJ Open, 9, e022642. https://doi.org/10.1136/bmjope....
 
35.
Paulides, E., Daker, C., Frampton, C., Gearry, R. B., Eglinton, T., de Boer, N. K. H., Bernstein, C. N., & McCombie, A. M. (2020). Overcoming workplace disability in IBD patients: an observational study. Inflammatory Intestinal Diseases, 5, 84–92. https://doi.org/10.1159/000506....
 
36.
Petrović, D. (2015, June). Ethics assessment in different countries: Serbia (Annex 4.h). In C. Shelley-Egan, P. Brey, R. Rodrigues, D. Douglas, A. Gurzawska, L. Bitsch, D. Wright, & K. Wadhwa (Eds.), Ethical assessment of re-search and innovation: a comparative analysis of practices and institutions in the EU and selected other countries (Deliverable 1.1). SATORI – Stakeholders Acting Together on the Ethical Impact Assessment of Research and Innovation.
 
37.
Philippou, A., Sehgal, P., Ungaro, R. C., Wang, K., Bagiella, E., Dubinsky, M. C., & Keefer, L. (2022). High levels of psychological resilience are associated with decreased anxiety in inflammatory bowel disease. Inflammatory Bowel Diseases, 28, 888–894. https://doi.org/10.1093/ibd/iz....
 
38.
Sehgal, P., Abrahams, E., Ungaro, R. C., Dubinsky, M., & Keefer, L. (2017). Resilience is associated with lower rates of depression and anxiety, and higher quality of life in inflammatory bowel disease patients. Gastroenterology, 152, S797–S798. https://doi.org/10.1016/S0016-....
 
39.
Sehgal, P., Ungaro, R. C., Foltz, C., Iacoviello, B., Dubinsky, M. C., & Keefer, L. (2020). High levels of psychological resilience associated with less disease activity, better quality of life, and fewer surgeries in inflammatory bowel disease. Inflammatory Bowel Diseases, 27, 791–796. https://doi.org/10.1093/ibd/iz....
 
40.
Shen, J. M., Zhang, Y., Xie, Y., Ye, H. L., Zhou, J. R., & Xie, S. Q. (2025). Moderating effects of resilience and de-pression on social support and life satisfaction in patients with IBD: a cross-sectional study. Scientific Reports, 15, 23263. https://doi.org/10.1038/s41598....
 
41.
Silangcruz, K., Nishimura, Y., Czech, T., Kimura, N., Hagiya, H., Koyama, T., & Otsuka, F. (2021). Impact of the World Inflammatory Bowel Disease Day and Crohn’s and Colitis Awareness Week on population interest be-tween 2016 and 2020: Google Trends analysis. JMIR Infodemiology, 1, e32856. https://doi.org/10.2196/32856.
 
42.
Taft, T. H., Ballou, S., Bedell, A., & Lincenberg, D. (2017). Psychological considerations and interventions in in-flammatory bowel disease patient care. Gastroenterology Clinics of North America, 46, 847–858. https://doi.org/10.1016/j.gtc.....
 
43.
Tang, L., & Lin, Z. (2024). The mediating and moderating role of resilience between stigma and illness identity among people with inflammatory bowel disease. Psychology Research & Behavior Management, 17, 1999–2009. https://doi.org/10.2147/PRBM.S....
 
44.
Taylor, K., Scruggs, P. W., Balemba, O. B., Wiest, M. M., & Vella, C. A. (2018). Associations between physical activ-ity, resilience, and quality of life in people with inflammatory bowel disease. European Journal of Applied Phys-iology, 118, 829–836. https://doi.org/10.1007/s00421....
 
45.
Thapwong, P., Norton, C., Terry, H., & Czuber-Dochan, W. (2022). Impact of inflammatory bowel disease on partners: a qualitative study. Gastrointestinal Nursing, 20, 40–50. https://doi.org/10.12968/gasn.....
 
46.
Tran, L., & Mulligan, K. (2019). A systematic review of self-management interventions for children and adoles-cents with inflammatory bowel disease. Inflammatory Bowel Diseases, 25, 685–698. https://doi.org/10.1093/ibd/iz....
 
47.
Trikoš, L. D. (2018). Individualni obrasci reagovanja na simptome bolesti kod obolelih od hroničnih zapaljenskih bolesti creva (Doktorska disertacija) [Individual patterns of reaction to disease symptoms in patients with chronic inflammatory bowel disease (Doctoral dissertation)]. Faculty of Medicine, University of Belgrade.
 
48.
Wagnild, G. M., & Young, H. M. (1993). Development and psychometric evaluation of the Resilience Scale. Journal of Nursing Measurement, 1, 165–178.
 
49.
Wang, M., Chen, X., He, J., Yang, C., Zeng, W., Bai, Y., Fan, H. & Sun, X. (2026). Association between metabolic syndrome and inflammatory bowel disease: a bidirectional two-sample Mendelian randomized study. Archives of Medical Science, 22, 365–376. https://doi.org/10.5114/aoms/2....
 
50.
Xu, Y., Liu, T., Jiang, Y., Zhao, X., Meng, F., Xu, G., & Zhao, M. (2022). Psychosocial adaptation among inflamma-tory bowel disease patients and associated factors: a cross-sectional study. Psychology Research and Behavior Management, 15, 2157–2167. https://doi.org/10.2147/PRBM.S....
 
Copyright: © Institute of Psychology, University of Gdansk This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2353-5571
ISSN:2353-4184
Journals System - logo
Scroll to top