ORIGINAL PAPER
HIV-related decreased brain activity during a semantic memory task is reflected in spontaneous brain functional connectivity
Harmonia Group
2,3,5,6,7,8
1
Faculty of Medicine, University of British Columbia, Vancouver, Canada
2
Faculty of Psychology, University of Warsaw, Warsaw, Poland
3
Institute of Physiology and Pathology of Hearing, World Hearing Center, Kajetany, Poland
4
Department of Adult Clinical Psychology, Institute of Psychology, The Maria Grzegorzewska University, Warsaw, Poland
5
The Central Hospital for Infectious Diseases, Warsaw, Poland
6
The College of Medicine, The Ohio State University, Columbus, OH, USA
7
The Cleveland Clinic, Cleveland, OH, USA
8
Institute of Psychiatry and Neurology, Warsaw, Poland
Submission date: 2020-02-19
Acceptance date: 2020-03-29
Online publication date: 2020-05-04
Publication date: 2020-04-28
Health Psychology Report 2020;8(2):120-135
KEYWORDS
TOPICS
ABSTRACT
Background:
The primary goal was to examine HIV-related changes in brain activation during a semantic memory task. The secondary goal was to assess whether the functional connectivity of the brain regions showing altered activity during the semantic memory task is related to HIV serostatus.
Participants and procedure:
The total group of 17 male subjects, aged on average 44 years, included 8 HIV+/cART+ and 9 demographically matched healthy comparators. Participants completed Famous Names Recognition task-functional magnetic resonance imaging (fMRI) and resting state fMRI.
Results:
We found an effect of HIV status on brain activation during the semantic memory task, despite comparable accuracy and reaction time across groups. Compared to healthy individuals, in HIV+ participants recognition of famous names elicited less activity in the fronto-striatal network, particularly in the left caudate nucleus (p = .049), left inferior frontal gyrus (p = .047), left thalamus (p = .031) and right thalamus (p = .047), as well as in the left middle occipital gyrus (p = .028). Although an effect of HIV status on functional connectivity of the brain regions showing altered activity during semantic memory task was not observed, resting-state activation of those regions was significantly correlated with performance on cognitive domains of attention, executive functioning, psychomotor speed and semantic skills.
Conclusions:
Our findings suggest the presence of functional brain network reorganization in HIV+/cART+ patients, particu-larly in subcortical regions of the fronto-striatal network, in the absence of neurocognitive decline.
The primary goal was to examine HIV-related changes in brain activation during a semantic memory task. The secondary goal was to assess whether the functional connectivity of the brain regions showing altered activity during the semantic memory task is related to HIV serostatus.
Participants and procedure:
The total group of 17 male subjects, aged on average 44 years, included 8 HIV+/cART+ and 9 demographically matched healthy comparators. Participants completed Famous Names Recognition task-functional magnetic resonance imaging (fMRI) and resting state fMRI.
Results:
We found an effect of HIV status on brain activation during the semantic memory task, despite comparable accuracy and reaction time across groups. Compared to healthy individuals, in HIV+ participants recognition of famous names elicited less activity in the fronto-striatal network, particularly in the left caudate nucleus (p = .049), left inferior frontal gyrus (p = .047), left thalamus (p = .031) and right thalamus (p = .047), as well as in the left middle occipital gyrus (p = .028). Although an effect of HIV status on functional connectivity of the brain regions showing altered activity during semantic memory task was not observed, resting-state activation of those regions was significantly correlated with performance on cognitive domains of attention, executive functioning, psychomotor speed and semantic skills.
Conclusions:
Our findings suggest the presence of functional brain network reorganization in HIV+/cART+ patients, particu-larly in subcortical regions of the fronto-striatal network, in the absence of neurocognitive decline.
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